Programmer not resp. after assigning pin0

Power resets, different cables, different ports, it all doenst matter.. when i hit Upload, the orange lights shortly blinks once. and then comes the error.

I cannot image that i a the only one with this problem. There must be someone else assigning pin 0 to something.. if that is the cause.

now can somebody please tell me HOW TO CLEAN IT UP? Reset, Format, Clear, Flash, Delete, Refresh, Start all over again.