I think the whole OSH model really denies standards to a certain extent. In designing the Pico one of my interests were to break a standard the Arduino Mini had adhered to that was first established by the BS2. A standard can really get in the way sometimes... look at the .1" pin spacing issue. With that said I still tried to stick to the Tx, Rx, +5v, Gnd, Rst pin order that Paul has somewhere on his BBB. I also bumped the Pico down to 24pins so that it could be used in a standard ic socket although Im not sure myself how practical that is. In the end Baskin Robins style every flavor has a purpose...
B