Arduino for Mac - avr-gcc: : No such file or directory

Have a look at this discussion: http://arduino.cc/forum/index.php/topic,147573.0.html and see if something applies to your case (ignore the part about Wiring). If not, you should provide more detailed information about your environment (OS version, IDE version), and post a full log of the error (hint: show verbose output in Arduino preferences).

Good luck!