Contemplating a long drive - Boston, MA to Columbus, OH

I've never driven either, just wondering if one was better than the other.

Southern Tier Expressway across NY, I have driven that. Tha-thump, tha-thump, tha-thump, all the way from the concrete slabs that make up the road, and stop lights. Gonna skip that for sure.

If I had a little more time I'd get current in my airplane again and just fly out, make 1 stop for gas & stretch the legs around Pittsburg.