My tip would be if you had the time to manually route the whole thing, on my projects I always do that and make every trace basically as big as possible (within reason) , also paying attention to special or sensitive traces or routing noiser ones elsewhere, I actually usually place components not where the ratsnest is easy but where. Its best for electrical reasons, with enough time you can figure out a way to make the most complex ratsnest work, trust me I've done a few where it looks so complex it just increases the cool factor 10x because its less random looking and look very fresh