For others searching for a solution, I was banging my head for awhile this morning trying to get my Mega 2560 board up and running on Arduino 22 on Windows Vista, and it couldn't find the drivers.
This is because it's an R3 board and R3's (the newest ones as of ~2012, and the ones sold at radio shack) have only been added to the Arduino since 23. You can see the change
log here..
On a side note thanks to the arduino team for having a release candidate for the R3 board before the 1.0 change that changed a bunch of stuff, in my case the serial libary hasn't been updated for 1.0 so it won't work there.