No. You'd need an ARM processor to push pixel data fast enough to use the LCD panel. There is no memory in the LCD panel, so you need to refresh it FAST. The touch is a simple 2-wire resistive, and you can use that quite simply on an Arduino.
The hardware as-is isn't usable with an Arduino, since it doesn't run WindowsCE underneath like almost all other GPS'es. It may run a variant of VxWorks, but last i checked my old Nüvi, the software ran directly on the hardware, no underlying OS.
// Per.