I had what I think is the same problem. I noticed it because my Vista machine would lock up totally (frozen UI requiring a hard power down to recover, not a blue screen crash) when I started sending lots of serial data back from the Arduino to the PC - it would work for a while but lock up after a couple of tens of kbytes of data had been sent back.
In my case it turned out that my original installation had an old driver for the FT232R serial to USB chip on my Diecimelia, I resolved my issues by upgrading to the V2.04.06 drivers from FTDI (available here:
http://www.ftdichip.com/Drivers/VCP.htm)