Yes there is a big difference between A and B,
A is common emitter and B is common collector.
With B you get no voltage gain (only current gain)
With A you get current gain (and voltage gain)
A will not work as the TLC output won't go high enough to turn the transistor off.
B is better in that respect but still will not work, again it won't switch correctly.
I will use two resistors before base on a PNP to reduce voltage on a TLC's output.
Not sure what you mean, why not one resistor twice the value?