i2c is capable of transferring data at a higher rate and leaves the asynchronous serial port available for uploading sketches and/or debugging. But if that doesn't matter for your application then no reason not to use async serial. The disadvantage of i2c is that it needs two pins (plus ground) even if the communication is one way, and the i2c pins must be analog pins 4 and 5, so thats two less analog inputs available.
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