XBee with tow Arduinos connected to Pc for programming

Can I have two UNO's with xBee radios connected to the same PC so that I can do sketch development on the PC and still have the two UNOs talking xBee when I test. BTW I have not used xBee but want to learn how to use it for arrays of sensors in a hydroponics setup. I have a mega interfaced to my PC control software now but want to get rid of lots of wires and have more localized activities going on. Just need to establish what the best development setup might be to get me started. Thanks for any help.