These are the basic troubleshooting steps and answers.
These steps may also save you some unnecessary time and effort in the forum.
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Always provide as much detail as possible to your issue it may be important.
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If applicable provide your SKETCH inside CODE TAGS ( </> ) or a CREATE share link.
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If applicable provide a schematic even if hand drawn.
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Pictures are an invaluable aid. See THIS TOPIC for help posting them.
COMMON ISSUES -
Check you have a COMMON GROUND where required.
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Where possible use USB 2.0 ports or a USB 2.0 POWERED HUB to rule out USB 3.0 issues.
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Try other computers where possible.
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Try other USB leads where possible.
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You may not have the correct driver installed. CH340/341 or CP2102
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There may be a problem with the board check your wiring first.
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Remove any items connected to pins 0 and 1.
COMPUTER RELATED -
Ensure you turn off any additional security / antivirus just to test.
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There may be a problem with the PC try RESTARTING it.
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You may be selecting the wrong COM port.
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Avoid cloud/network based installations where possible OR ensure your Network/Cloud software is RUNNING.
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Clear your browsers CACHE.
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If using CREATE then try and INCOGNITO window or similar to rule out browser add-on's.
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Close the IDE before using any other serial programs.
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Preferably install IDE's as ADMINISTRATOR or your OS equivalent
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If you have tried multiple IDE's then you may need to perform additional clean up.
Performing the above actions may help resolve your problem without further help.