Not all 100 pins of ATMega 2560 are used in arduino mega

i have been using 7"tft and various other library so in total i only get 37 i/o pins on arduino mega 2560 so i saw the schematic of it i saw that 16 pins are unused which are general purpose i/o only.
and all of them are listed above.i want to use all the 16 pins (total 37+ 16 =53)so what all should be done
like sholdering or adding diffrent library or modyfing please tell me about it