Arduino 101 Error: device not responding.

I've been experiencing the same problem. A project I started under the previous version of the IDE now yields the same error you mentioned. Version 1.0.4 of the Curie library was included with that previous version of the IDE.

My curiosity is if some of the tooling now fails with USB3 ports.

My setup: Retina MacBook Pro (all USB3 ports) and the Arduino 101.

NOTE: I have tried removing application and all supporting library folders and reinstalling with no luck.