Air Pressure - SM5420C

If you only want to detect a (big) change in pressure, then connect the two outputs of the sensor to two analogue inputs.
Subtract the two A/D values you get from each other to find the difference (positive or negative).
Don't expect a lot from these unamplified sensors (~20 A/D values over the whole pressure range).
You should have bought sensors with buildin instrumentation amp.
Leo..