Specific OS ?
Specific computer hardware (please dont say a win tablet or an android device) ?
Steps taken ?
Without SPECIFICS it is almost impossible to help anyone
My 101 had some initial driver issues but it didnt take me long to figure it out.
I downloaded the specific driver from INTEL (yes its is thier hardware) and once I had those in I re-installed the boards package in the regular IDE and my driver issues were fixed.