I have to agree with DrAzzy.
Toner transfer is just too fast to be neglected. Most of my projects are single boards, and only sometimes two or three. My largest run was about 20 boards, but in that case the board was absolutely tiny (10 x 6 mm), so again, only one etching process.
After I finish the design, the printing takes minutes. Ironing is also fast (it takes more for the iron to heat up than to actually iron).
As for the cost, 1,2 m2 of vinyl cost me around $6 (and you can make a lot of boards from that sheet). I etch with hydrochloric acid (36%) and peroxide (30%). I "liberated" a bottle of each for free from my mum's lab and reuse it. I expect those to last me a long time.
As Nick says, drilling is the tricky part, but I've learned that using 0 Ohm SMD resistors for jumpers significantly reduces the number of holes. I try to use SMD as much as I can. For the stuff that needs to be through hole, I use slightly larger pads with smaller holes and tin them before drilling. This adds a layer of solder that guides the drill bit to the center of the pad. I use carbide bits from ebay and a very old (and a bit wobbly) drill press. If one or two holes do end up misaligned, in almost all cases pins can be persuaded to go through. I also use slightly oversized holes (if a lead snugly fits in a 0,8mm hole, I dill 0,9mm or 1mm).