I'm not quite sure what you are asking.
But, you can communicate from a VB program with Arduino.
So if you want to send some kind of data from a VB program to Arduino it is possible. Just remember that the USB port on Arduino is really a serial port, so in the VB program you must send data out the correct serial (COM) port.
How you do that depends on what version of VB ( VB 6.0 or earlier or VB.net) you are working with.