About ESP32 connected to The Things Network

I am now connecting a node to the TTN by the tutorial website:

But When getting my device EUI and uploading, it said : avrdude:error:programmer did not respond to command:exit bootloader

I used the MCU: esp32 and lora chip:RN2483.

I want to know is it something wrong with my usb cable or something wrong with my connection?

Thanks.