10 failed upload attempts with VR connected via RxTx

I'm trying to get a combo with Nano and VR to work. Uploading sketch from the samples provided it does compile and upload no problem. But as soon as I try the same with the VR board connected I get 10 failed attempts to upload with error:

avrdude: stk500_getsync () attempt 9 of 10: not in sync: resp=0xc3 avrdude: stk500_recv () : programmer is not responding avrdude: stk500_getsync () attempt 10 of 10: not in sync: resp=0xc3

Trying the commands specified, e.g. "settings" there is no response from the VR board. I tried two VR boards already. What is going on here?

(deleted)

Sorry, Voice Recognition module. http://www.elechouse.com/elechouse/index.php?main_page=product_info&cPath=168_170&products_id=2254

Are you using the pins you are supposed to 2 & 3 ?

The manual is quite specific bout those pins.
So when you say TX & RX we would normally assume 0 and 1 which are used during UPLOAD and mean you would have to disconnect something before trying to upload.