Please tell us about your project. There might be many ways to solve a problem.
Do you use VirtualWire with TIMER1 ? Or do you need specific timing ? What receiver are you using ?
As far as I know, the Wire library does not use TIMER1, so it should not be a problem.
However, the I2C interrupts will interfere with TIMER1 interrupts.
Perhaps you can use a software I2C or SPI bus with software pin toggle. What device is connected to the I2C bus ?