Arduino 1.8.5 OSX stops working after library update?

This is driving me insane! I have two OSX computers both running MacOS Mojave beta. both running latest IDE. My computer in my office worked perfect after MacOS beta install and fresh IDE install, and then stopped after the auto update. It now says my user version of /user/library/.avrdudeconfig file is missing? makes 10 attempts to upload and times out? I can see the port, it comes and goes if I plug/unplug the Ardino? The computer i am writing this on is a Mini with same specs as above, except I interrupted the auto update and it see's and writes to a Uno and Nano both plugged in at once. Just pick the right port. What is the auto update writing?

You've been extremely vague so I'm going to just take a wild guess that you're trying to upload to either a clone Nano or an old official Nano. With the latest version of Arduino AVR Boards it's now necessary to select Tools > Processor > ATmega328P (Old Bootloader).

The board shows when I plug in, won't upload. Sorry for being so vague! I have installed a blanc .avrduderc file, please see error message Thanks in advance!:

avrdude: Version 6.3, compiled on Jan 17 2017 at 12:01:35
Copyright (c) 2000-2005 Brian Dean, http://www.bdmicro.com/
Copyright (c) 2007-2014 Joerg Wunsch

System wide configuration file is "/Applications/Arduino.app/Contents/Java/hardware/tools/avr/etc/avrdude.conf"
User configuration file is "/Users/robert/.avrduderc"
User configuration file does not exist or is not a regular file, skipping

Using Port : /dev/cu.usbserial-5D10
Using Programmer : arduino
Overriding Baud Rate : 115200
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 1 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 2 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding

SOLVED @#$%&!$#@ing Apple SIP!!! I had to fight with that bullsh1t to install a signed driver. finally my 12 core updated Mac Pro will do what a crap Mini will do. Upload a sketch to an arduino. My tech foo was taxed hard on this one! Moral? Disable SIP before doing anything interesting! @#%$^& YOU APPLE SIP too agressive!