Arduino 33 ble sense

Hello,
I'm just asking about how to connect Arduino 33 ble sense with esp8266 to send data

Serial port, I2C, SPI, BT,... plenty of options

Mean that can't connect with esp??

I mean you have many ways to connect the two. The question is more what are you trying to accomplish, what are the constraints etc… in one word : you need specifications for the objective