Arduino IDE Cannot connect to Arduino MEGA 2560

I am trying to get the Arduino IDE to communicate with an Arduino Mega 2560 and I get the following error message.

avrdude: ser_open(): can't open device "\\.\COM4": The system cannot find the file specified.

avrdude: ser_drain(): read error: The handle is invalid.

Here are some details.

Using windows 7 Running Arduino IDE Version 1.6.4 Windows Device manager shows Arduino Mega 2560 (COM4) I have selected Tools, Board, to show the Arduino Mega or Mega 2560 I have selected Tools, Port to be COM4 To start I am attempting to send the code for the "Blink" example.

I have read through many posts discussing this issue, but nothing has yet worked in this case. Any assistance would be greatly appreciated. Thank you for your time.