arduino mega 2560 using sketch: error message serial port does not exist

my complete error message

Arduino: 1.8.5 (Windows Vista), Board: "Arduino/Genuino Mega or Mega 2560, ATmega2560 (Mega 2560)"

Sketch uses 2956 bytes (1%) of program storage space. Maximum is 253952 bytes.
Global variables use 376 bytes (4%) of dynamic memory, leaving 7816 bytes for local variables. Maximum is 8192 bytes.
avrdude: ser_open(): can't open device "\.\COM1": The system cannot find the file specified.

avrdude: ser_drain(): read error: The handle is invalid.

avrdude: ser_send(): write error: sorry no info avail
avrdude: stk500_send(): failed to send command to serial port
avrdude: ser_recv(): read error: The handle is invalid.

avrdude: stk500v2_ReceiveMessage(): timeout
avrdude: ser_send(): write error: sorry no info avail
avrdude: stk500_send(): failed to send command to serial port
avrdude: ser_recv(): read error: The handle is invalid.

avrdude: stk500v2_ReceiveMessage(): timeout
avrdude: ser_send(): write error: sorry no info avail
avrdude: stk500_send(): failed to send command to serial port
avrdude: ser_recv(): read error: The handle is invalid.

avrdude: stk500v2_ReceiveMessage(): timeout
avrdude: ser_send(): write error: sorry no info avail
avrdude: stk500_send(): failed to send command to serial port
avrdude: ser_recv(): read error: The handle is invalid.

the selected serial port
does not exist or your board is not connected
avrdude: stk500v2_ReceiveMessage(): timeout
avrdude: ser_send(): write error: sorry no info avail
avrdude: stk500_send(): failed to send command to serial port
avrdude: ser_recv(): read error: The handle is invalid.

avrdude: stk500v2_ReceiveMessage(): timeout
avrdude: ser_send(): write error: sorry no info avail
avrdude: stk500_send(): failed to send command to serial port
avrdude: ser_recv(): read error: The handle is invalid.

avrdude: stk500v2_ReceiveMessage(): timeout
avrdude: stk500v2_getsync(): timeout communicating with programmer

This report would have more information with
"Show verbose output during compilation"
option enabled in File -> Preferences.