Arduino MKR and SAML21

I'm looking to do an embedded project with a custom board, programmed with the Arduino IDE and libraries. I have been prototyping on a MKR Zero which uses the SAMD21 microcontroller and am ready to move to design of the physical board.

The global chip shortage has bitten me and I cannot source any SAMD21G18A chips until about March next year.

In the interim I'm looking at the low power version, SAML21G18B, as a drop in replacement to get my hardware under way.

Are there any pitfalls, or differences I should be aware of ?

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