Arduino nano 33 iot no working

Hello, I recently made an arduino nano 33 iot, which at the beginning was totally fine, after some tests the arduino is not recognized by any computer, when I press the reset button twice the led does not flash, I would like to be able to solve it, now I installed, deleted and reinstalled the drivers the same with the arduino ide, and tried with different usb clabes

try to burn the bootloader again

Where can I find more information about the subject? Look at a CMSIS on aliexpress but I don't know if it will be possible with that

you write that you made the board. I assumed you had to put the bootloader into the SAMD21

If I read in that forum, that's why I ask if any cmsis programmer can work, this is the link I saw on aliexpress

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