Arduino on NucleoF401RE rx/tx ,i2c problem

Hi, on my F401RE Nucleo the Rx/Tx and I2C modes do not work. When attaching an I2C sensor type MLX90614 or BME280 the serial monitor does not work.
The same for the Nextion display on rx/tx doesn't work, it doesn't receive anything.
A led, blink program, works on almost all pins.
Any idea?
Graze
chipxx