I've been experimenting with my Arduino Pro Mini 5v 16hz quite a bit recently and using the Arduino usb2serial adapter. Most of the time things seem ok, but now and again I get programmer is not responding, then I have to force quit (Mac) and restart the computer until it works again. I have made sure on all occasions that these are selected from the tools menu:
Arduino Pro Mini 328 5v
Is there anything else I should be doing or not doing?