Since its an arm cortex m4, one might assume that some genius could compile the micropython sources thru the ARM-GCC compiler. Right now I'd be Real Happy if I could dl pdf versions of the arduino html files for the Arduino docs. Us old guys want the cheat sheet in view while we are editing.
Circuit Python is a lot more popular, runs on ARM MCUs, and there seem to be many fewer complaints about functionality. Since it is a C program, it might run on the Uno R4. Ask Adafruit.
I personally don't see any point in using Python on an MCU, but have fun!
@ubidefeo commented about this here for the R4 WiFi...
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You might also be interested in uLisp, a Lisp interpreter for the Uno R4 boards: