Arduino uploading quit working on PC

I am new to Arduino and have been successfully loading and running sketches using UNO. Everything was working fine and then just quit. I was connecting and disconnecting the USB cable to test without the USB. The status says it uploaded, but the sketches don't update anymore. I see the Rx LED on the UNO flash a couple of times but no Tx LED indication. Normal upload the Rx and Tx LEDs flash during the upload. I have moved the UNO to a different PC and it works fine.

So something has happen in my Serial communications on this PC. I removed the Arduino IDE and reinstalled the program, but no improvement. I have confirmed the correct COM ports. The Arduino appears to working fine, but not this PC Serial communication.

Has anyone experienced this and does anyone have a suggestions?