CrossRoads:
Does the PL2303 have a DTR, RST, anything you can break out to a pin to drive a capacitor for a DTR signal? Many CP2102 boards do.
DOH!!! I really should have thought of that one myself shouldn't I?
The Data Sheet shows Pin 2 as DTR_N. Looks like I might have to try my first bit of hand soldering to a SMD.