Hi pert,
thanks for your suggestion.
It will be helpful to have bootlader so I can easily upload new sketch using USB. But it is not essential.
Host machine always send data, it can happen in 300ms or 10ms, you never know.
I changed high fuse to D9 and uploaded sketch using USBASP and know arduino boot immediately and doesn't lock on startup.
mega.menu.cpu.atmega2560.bootloader.high_fuses=0xD9
It is working, thanks pert 