avrdude: ser_open(): can't open device

Using Arduino IDE 1.x
1

Arduino IDE Issue Uploading sketches to Arduino Nano

NOTEs:

  • Tried all ports, all report the same error code, no new ports become available.
  • Tried alternative, Processor: ATmega328P (Old Bootloader), no difference.
  • There are no connections to the Nano board, it is not connected to anything but the micro USB.
  • Uninstalled Arduino IDE twice and reinstalled twice, no change.
  • Up graded Big Sur OS 11.1, to see if drivers may of been updated, no change.
  • Norton anti virus has been disconnected and system has been rebooted, no change.
  • Checked the drivers from ”FTDIUSBSerialDriver_v2_4_4.dmg”, no change.
  • About 4 weeks ago I wrote a sketch for 16x32 DMD, and it worked perfectly, today I cannot even load the “blink” sketch without getting this error.

Seeking a clue please.

Tools
Board: Arduino NANO
Processor: ATmega328P
Port: “/dev/cu.00-17-53-57-4c-f9-SPPDev”
Programmer: Arduino as ISP

Error code:

Arduino: 1.8.13 (Mac OS X), Board: "Arduino Nano, ATmega328P"

Sketch uses 924 bytes (3%) of program storage space. Maximum is 30720 bytes.
Global variables use 9 bytes (0%) of dynamic memory, leaving 2039 bytes for local variables. Maximum is 2048 bytes.
/Users/glenysambe/Library/Arduino15/packages/arduino/tools/avrdude/6.3.0-arduino17/bin/avrdude -C/Users/glenysambe/Library/Arduino15/packages/arduino/tools/avrdude/6.3.0-arduino17/etc/avrdude.conf -v -patmega328p -carduino -P/dev/cu.00-17-53-57-4c-f9-SPPDev -b115200 -D -Uflash:w:/var/folders/pl/rw94w7_x3z35h1zzmgjc674c0000gn/T/arduino_build_124010/Blink.ino.hex:i

avrdude: Version 6.3-20190619
Copyright (c) 2000-2005 Brian Dean, http://www.bdmicro.com/
Copyright (c) 2007-2014 Joerg Wunsch

System wide configuration file is "/Users/glenysambe/Library/Arduino15/packages/arduino/tools/avrdude/6.3.0-arduino17/etc/avrdude.conf"
User configuration file is "/Users/glenysambe/.avrduderc"
User configuration file does not exist or is not a regular file, skipping

Using Port : /dev/cu.00-17-53-57-4c-f9-SPPDev
Using Programmer : arduino
Overriding Baud Rate : 115200
avrdude: ser_open(): can't open device "/dev/cu.00-17-53-57-4c-f9-SPPDev": Resource busy

avrdude done. Thank you.