Best way to control 64x64 rgb leds?

How would i go about performing this with an arduino? I have an uno, would I have to use shift registers? Multiple arduinos? I really don't know where to begin.

Many thanks for any help at all,

Sam

You will almost certainly need shift registers, and lots of them!

You either need 12288 outputs (1536 8-bit shift registers) or you need a multiplexed array (say, 32x384 LEDs or 4+48 8-bit shift registers) or maybe you can use 8x8 modules (64 of them) each with three 8x8 driver chips.