BMP280 blocking the I2C bus

If the BMP280 sensor is not present or has been damaged/removed while sketch starting or running, it will block/freeze the whole I2C bus and also the loop execution process.

Any thoughts about this?

Mmm... After 140 posts I would have thought you have read the sticky by now and know how to ask a question. Iow: the information provided is totally insufficient. No code, wiring, photos, clear problem description, etc.

That will happen with any device attached to any pins or bus if the program code asks for and then waits indefinitely for a response from the device.

I suggest trying a different library.