Cant find COM8

It gives me this error msg

Binary sketch size: 2,418 bytes (of a 32,256 byte maximum)
processing.app.SerialNotFoundException: Serial port 'COM8' not found. Did you select the right one from the Tools > Serial Port menu?
at processing.app.Serial.(Serial.java:191)
at processing.app.Serial.(Serial.java:77)
at processing.app.debug.Uploader.flushSerialBuffer(Uploader.java:77)
at processing.app.debug.AvrdudeUploader.uploadViaBootloader(AvrdudeUploader.java:172)
at processing.app.debug.AvrdudeUploader.uploadUsingPreferences(AvrdudeUploader.java:67)
at processing.app.Sketch.upload(Sketch.java:1706)
at processing.app.Sketch.exportApplet(Sketch.java:1662)
at processing.app.Sketch.exportApplet(Sketch.java:1634)
at processing.app.Editor$DefaultExportHandler.run(Editor.java:2346)
at java.lang.Thread.run(Thread.java:619)

When I go to device manager, it tells me Arduino Uno R3 (COM8), so I dont know what to do. Please help me out !

Try simple first.
Unplug the Arduino
Reboot the computer
Plug in the Arduino
Start the Arduino IDE

Sometimes windows serial port handling can get flaky.

Well, if you are able to upload something sometimes, I suggest you to test http://arduino.cc/forum/index.php/topic,118440.0.html because the "wrapper" in avrdude will attempt to 'disable/reenable' the plugged arduinos on failure.

Otherwise, smeezekitty solution is the way to go first.