Can't upload sketch to Mega 2560

Cought the same problem today, as a lot of people have with arduino Mega
Compiler just saying trying to upload sketch,but at the end it just stops.If I unplugg the USB it says
avrdude: stk500v2_ReceiveMessage(): timeout
Other topics can't help me
And it's not the problem with !!!
Can you possible say what to do in steps to take away this problem, please.

If you get this sorted...LET THE WORLD KNOW!!
Are you using a Mac or Windoze??

I'm using just Windows 7 x64