I had many problems connecting with the BLE.
It would talk but would hang.
After a download the serial monitor would not work.
If your comm ports all say CH340 you need to install a different driver designed for the NANO 33 BLE.
It was supposed to install when I installed the board but didn't.
I'm sorry but It has been so long that I don't remember exactly the location of the driver.
After installing your device manager will say "Arduino nano 33 ble.
It is a pleasure (almost) working with the BLE now.
Good Luck
LAPLACE888