Communication Error - Arduino Mega 2560 STK500v2 to T100 thru BlueESC

see attached files
looked at students project - they are getting error -Receive Message () : timeout
getsync() timeout communication with programmer
I tried to trace but it appears that the blueesc is not communicating w/ the Mega I don't know why
I'm ( retired engineer ) more familiar with the Parallax boards and software and the kids are working with the Arduino Mega 2560 and a laptop and these truster with a Blue ESC controller
Am I describing the issues correctly and
Can you point me in the right direction - where should I look for a potential cause(s)
I upload the attachments for reference

Note ; the students are using "second Method" in the Blue Doc ( Assigning I^2 C Addresses)
Try told me they tried the first method ( I personally would have worked with the first method )

I noticed in your literature a statement Com port recognition on a Windows machine a inf.file should I be concerned about that ?

If you want to call me to discuss send me an email and I'll give you my phone #
EMAIL REMOVED (mod edit)
Thanks

Are you able to upload a simple sketch to a naked Mega 2560?