I have no clue about Labview... In Python, I open the port and wait for a little (e.g. 3 seconds) then I have to fiddle with getting the microcontroller into a state that it is expecting to receive a command. Once the command is sent I get data back. I do this in part to make sure I am working with data that was not buffered by the OS. I format the data output from the microcontroller as JSON which I can then convert into a Python object and pass that to the toys that Jupiter notebooks offer.