Disappearing Port on the Mac

I have found others asking the same question, suddenly your Arduino USB port becomes disabled and you can no longer upload your sketch.

Error shows as: can't open device "/dev/cu.usbmodem14201": No such file or directory

The problem occurs when you draw too much power from your USB connected Arduino. I suspected this because it occurred when I set my LED strip to max brightness. Dimming the brightness solved the issue.

Once the board is kicked out of the bus you need to unplug-replug your USB cable.