That is simply NOT true! It is true ONLY from the point of view of SOME humans. I, and many others, am perfectly comfortable with EITHER, and I could not care less which one any given processor uses. If you took a poll, you would find there are just as many people who feel big-endian is "more natural" as there are who feel little-endian is "more natural". Don't ascribe your personal bias to the entire species. It is a personal preference, and nothing more.