Error "did not find USB..." Upload Using Programmer

Windows 10 pro, IDE 1.8.12, Mega 2560

Very new to Arduino... Getting this error when I try to Upload Using Programmer;


avrdude: Version 6.3-20190619
Copyright (c) 2000-2005 Brian Dean, http://www.bdmicro.com/
Copyright (c) 2007-2014 Joerg Wunsch

System wide configuration file is "C:\Program Files\WindowsApps\ArduinoLLC.ArduinoIDE_1.8.33.0_x86__mdqgnx93n4wtt\hardware\tools\avr/etc/avrdude.conf"

Using Port : usb
Using Programmer : stk500v2
avrdude: usbdev_open(): did not find any USB device "usb" (0x03eb:0x2104)

avrdude done. Thank you.

An error occurred while uploading the sketch

I get the same error when I try to burn the bootloader.

I can upload a sketch no problem.

BN: Arduino Mega or Mega 2560
VID: 0x2341
PID: 0x0042
SN: 85734323331351711170

So I must have the correct port etc....

-TIA

What hardware programmer you are using ?