error upload a sketch

Arduino: 1.8.5 (Mac OS X), Board: "Arduino/Genuino Uno"

avrdude: stk500_recv(): programmer is not responding
Sketch uses 928 bytes (2%) of program storage space. Maximum is 32256 bytes.
Global variables use 9 bytes (0%) of dynamic memory, leaving 2039 bytes for local variables. Maximum is 2048 bytes.
Problem uploading to board. See http://www.arduino.cc/en/Guide/Troubleshooting#upload for suggestions.
avrdude: stk500_recv(): programmer is not responding

This report would have more information with
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system
OS X 10.11.5 (El Capitan)
Brand new Arduino uno R3 328 board

CH340 driver ?

ieee488:
CH340 driver ?

What is that driver and do I need it or do I need to remove it.