error when upload

Development Tools Uploading
1 

avrdude: stk500_paged_load(): (a) protocol error, expect=0x10, resp=0x00
avrdude: stk500_cmd(): programmer is out of sync
avr_read(): error reading address 0x0000
    read operation not supported for memory "flash"
avrdude: failed to read all of flash memory, rc=-2
avrdude: stk500_disable(): protocol error, expect=0x14, resp=0x00
avrdude: stk500_disable(): protocol error, expect=0x14, resp=0x00
2

What hardware is involved? What command line leaded to this error?