Error with linking board

program with Visual Studios 2017 Student version,
We just started today I try to do the Blink Function but then this message comes after I built&upload

Error linking for board Arduino/Genuino Mega w/ ATmega2560 (Mega 2560)
Build failed for project 'Übung 1'
ld.exe: cannot open output file C:\Users\paulw\AppData\Local\Temp\VMBuilds\Übung 1\mega_atmega2560\Release\Übung 1.ino.elf: Permission denied

collect2.exe*: error: ld returned 1 exit status

Please help me.
Thanks

Do you have any anti virus software running ?
McAfee, for instance, uses "on access" scanning and opens files to check them which prevents the compiler/linker using them at the same time, thus causing an error like yours.