Failed uploading

IDE 2.0.3: All of a sudden uploading fails, happened numerous times. Seems to be an issue of the IDE. See copy of 'red' upload comment, the last line seems incorrect, it is COM5 but not \.\ etc.
Is this known? Am I doing something wrong?

     Using Port                    : COM5
     Using Programmer              : arduino
     Overriding Baud Rate          : 57600

avrdude: ser_open(): can't set com-state for "\.\COM5"

Interesting! I think it is the thing on the left that is giving you problems, but not sure. What do you have?

Don't know exactly what you mean with "What do you have", hardware?
The development IDE is on a Windows PC, the arduino hardware is a A-star board, 328PB CPU running at 8MHz, 3V3. There is a pololu programmer board inbetween. I use this setup for longer time, never had issues, but that was an older IDE version.

In your IDE, verify:
TOOLS >> PORT >> (your port)
TOOLS >> BOARD >> (your board)
TOOLS >> PROCESSOR >> (your processor)

That is the notation, nothing to worry about. If your COM port has double digits, it's the only way to acces them.

The Pololu programmers that I know can upload via serial or via icsp; which one do you use.

Please post a link to the board. Did you select the correct board and, more important, the correct speed?

tools
COM5 (I know this is the correct port, checked with device manager)
Board: Pololu A-star 328PB
Version: 8MHz, 3v3 (which is correct)
Programmer: STK500 for pololu A-start 328PB
Note: I use this board for multiple projects, one of them is developed to production quality, meaning all bugs in libs solved, etc. Meaning I use these settings for a long time and know for sure that they are correct. The problem started with this IDE version 2.0.3. Before I used version 1.8.13. I can thus not confirm if it has issues in inbetween releases.

Calling @ptillisch