I am logging right now using VB.NET 2010 and an arduino dumilenove conected via USB.
I use a serial object to connect to the correct serial port, once connected I read a CSV line from the serial (I usually proceed with $ for info ^ for data line etc), then use a thread to triger if any serial info is recieved! fairly simple, I can give the code, its not the best but it graphs my 3 variables, has a log window showing all input and output to the logger.
Also I added buttons to set the RTC to system time and clear windows etc!