ZinggJM:
Your Arduino MEGA has not enough RAM to buffer the content of the whole screen. You need to use paged drawing. See example PagedDisplayExampleSmallRam.inoOr you can use GxEPD2_AVR which does paged drawing using picture loop. See GxEPD2_AVR_Example.
Thanks a lot ZinggJM, i go to try it.
Regards.